Transplant immunology I: mechanisms of rejection in solid organ transplants
نویسندگان
چکیده
Non-identical transplants (allogeneic) have been a modern medicine milestone; however, the major pitfall for completed succeed is recognition of foreign organ by immune system. The myriad variations in sequence molecules histocompatibility complex (MHC) or human leukocyte antigen (HLA) between individuals are cause allograft rejection. Thus, B T lymphocytes receptor occurs hypervariable regions HLA that triggers to graft 3 types rejection: hyperacute, acute, and chronic. In addition, rejection could be antibody-mediated (ABMR), T-cell-mediated (TCMR), both, which depends on main branch This review will explore mechanisms mentioned above give an introductory insight into transplant immunology; thus, preparer reader delve further reviews Histocompatibility Immunogenetics laboratory purpose.
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ژورنال
عنوان ژورنال: Journal of Stem Cell Research & Therapeutics
سال: 2022
ISSN: ['2475-5540']
DOI: https://doi.org/10.15406/jsrt.2022.07.00152